Meindert Danhof is Professor of Pharmacology and Director of the Leiden-Amsterdam Center for Drug Research at Leiden University in the Netherlands. Dr. Danhof received a MSc in Pharmacy with specialization in Pharmacology (cum laude) and a PharmD from the University of Groningen in 1975 and 1976 respectively. He received a Ph.D. in Pharmacology (cum laude) from the University of Leiden in 1980. Subsequently he has received further specialist training in pharmacokinetics-pharmacodynamics as a post-doctoral research fellow at the State University of New York in Buffalo, NY, USA (1980-1983) and at Stanford University Medical School, Stanford, CA, USA (1983-1986). He is certified as a Clinical Pharmacologist and as an Experimental Pharmacologist in the Netherlands. Dr. Danhof's research interest is in the development of new theoretical concepts in pharmacokinetic-pharmacodynamic (PK-PD) modeling. In recent years important contributions in his research have been on the incorporation of i) receptor theory and ii) dynamical systems analysis. This has resulted in a new class of 'mechanism-based' PK-PD models with considerably improved properties for extrapolation and prediction. His latest contribution has been the introduction of the concept of disease system analysis. Dr. Danhof is the Principle Investigator of the "TIPharma Mechanism-based PK-PD Modeling Platform", which was founded in 2007 and aims at the development of a mechanism-based PK-PD model library and database for utilization in drug discovery and development. Partners in this platform are 6 leading international pharmaceutical companies, who have agreed to the sharing of data for the purpose of mechanism-based PK-PD model building. He is the Founder and Chairman of the series of international conferences "Measurement and Kinetics of In Vivo Drug Effects' in Noordwijkerhout, the Netherlands in 1990, 1994, 1998, 2002 and 2006. He is also the Founder LAP&P Consultants BV, which provides a professional infrastructure for consultancy on advanced PK-PD modelling to the pharmaceutical industry. Dr. Danhof has been an AAPS Fellow since 1998. He has received the "Organon Research Prize" in 1993, the "FIP Pharmaceutical Scientist of the Year Award" in 1997 and the "Rawls Palmer Award" of the American Society for Clinical Pharmacology and Therapeutics in 2004 and the "EUFEPS New Safe Medicines Faster Award" of the European Federation of Pharmaceutical Sciences in 2006. Dr. Danhof is author of 291 publications in peer reviewed international scientific journals and listed on the ISI-list of Highly Cited researchers [www.isihighlycited.com]