Dr Nicholas HG Holford, MBChB, FRACP is Associate Professor of Clinical Pharmacology at the University of Auckland. He is also an Honorary Professor at the University of Queensland and Adjunct Professor at the University of California San Francisco. His research interests include population PKPD analyses of clinical trials of drugs, clinical trial simulation, PKPD in neonates and children and rational approaches to anti-cancer drug use. He is currently developing the use of disease progress models for understanding clinical pharmacology with an emphasis on the effects of levodopa in Parkinson's Disease, drugs affecting post-menopausal bone loss, the time course of response to anti-depressants and the progression of diabetes mellitus.