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Registration Info | Hotel Info | Transportation | Visiting Tucson
Program
Additional abstracts and bios will be posted soon. Check back often for updates!
Last updated: 2008-Mar-25
| Time | Event | Presenter | |
|---|---|---|---|
| SUNDAY MARCH 9 | |||
| 8:00 am -4:30 pm | Pre-meeting workshop: Getting Started with Bayesian PK/PD Modeling and Simulation Using WinBUGS | William Gillespie and Metrum Institute staff | |
| 8:00 am -4:30 pm | Pre-meeting workshop: R for Pharmacometricians | Richard Pugh and Mango Solutions staff | |
| 3:00 -7:00 pm | Registration | ||
| 7:00 - 9:00 pm | ACoP Opening Reception | ||
| MONDAY MARCH 10 | |||
| 7:30-8:30 am | Breakfast/Registration | ||
| 8:30-8:45 am | Welcome - Slides (PPT 8.6MB) | Stacey Tannenbaum (bio) | |
| 8:45-9:00 am | The Critical Path Institute: Creating an environment for innovation and change - Abstract (PDF); Slides (PDF) | Raymond Woosley (bio) | |
| 9:00-10:30 am | Focus Session 1: Model-based drug development:
Future or Fantasy? Session Chairs: Stacey Tannenbaum and Marc Pfister |
||
| Implementation and Management of Modeling and Simulation in Pharma: Presentations and Panel Discussion - Abstract (PDF); Slides (PDF, PDF) | Sandy Allerheiligen (bio), Richard Lalonde (bio), Marc Pfister (bio), Don Stanski (bio) |
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| 10:30-11:30 am | Break/Posters/Software Demos | ||
| 11:30 am -1:05 pm |
Focus Session 2a: Mechanistic Modeling/Systems Biology Session Chairs: David D'Argenio and William Jusko |
||
| Opening remarks on modeling in biomedical research (PDF) | David D’Argenio (bio) | ||
| Pharmacodynamics and Pharmacogenomics of Corticosteroids: Towards Systems Analysis - Abstract (PDF); Slides (PDF) | William Jusko (bio) | ||
| Dynamic Pharmacodynamics: Modeling and Optimization - Abstract (PDF); Slides (PDF) | Ron Siegel (bio) | ||
| Modeling Wnt signaling pathway and its regulation of bone mass - Abstract (PDF); Slides (PDF) | Anna Georgieva (bio) | ||
| Mechanistic modeling of gastro-esophageal function: A model-based measurement of muscle tone in reflux disease - Abstract (PDF); Slides (PDF) | Ramprasad Ramakrishna (bio) | ||
| 1:05 - 2:05 | Lunch/Posters/Software Demos | ||
| 2:05-3:35 PM | Focus Session 2b: Mechanistic Modeling/Systems Biology Session Chairs: David D'Argenio and William Jusko |
||
| Mechanism-Based PD Modeling for Predicting Exposure Response - Abstract (PDF); Slides (PDF) | Meindert Danhof (bio) | ||
| Applications of a Mechanistic Physiologic Based Pharmacokinetic Model for Imaging Agent Development - Abstract (PDF); Slides (PDF) | Mary Spilker (bio) | ||
| Mechanistic Modeling of Magnetically Marked Extended Release Formulation of Felodipine - Abstract (PDF); Slides (PDF) | Martin Bergstrand (bio) | ||
| Mechanism-Based Modeling and Simulation Strategies for 2nd Generation Molecule Development Life-Cycle Fast Tracking: A High-affinity Anti-IgE (HAE1) Monoclonal Antibody Case Study | Nelson "Shasha" Jumbe (bio) | ||
| 3:35-4:35 PM | Break/Posters/Software Demos | ||
| 4:35-5:20 PM | Lewis B. Sheiner Lecture Session Chairs: Nancy Sambol and Les Benet |
||
| Lessons from Lewis - How to Stir the Pot! - Abstract (PDF); Slides (PDF) | Carl Peck (bio) | ||
| 5:30-7:30 PM | ACoP Cocktail Reception/Posters | ||
| 8:00 - 9:00 PM | Stargazing lecture | Matt Kenworthy U of Arizona Dept. of Astronomy |
|
| TUESDAY MARCH 11 | |||
| 7:30-8:30 am | Breakfast | ||
| 8:30-10:20 am | Focus Session 3: Tools and Techniques Session Chairs: Mats Karlsson and Paolo Vicini |
||
| Time to get intimate with your tools – a demonstration - Abstract (PDF); Slides (PDF) | Mats Karlsson (bio) | ||
| Stochastic EM algorithms in population pharmacokinetic-pharmacodynamic analyses - Abstract (PDF); Slides (PDF) | France Mentré (bio) | ||
| Sequential parametric-nonparametric modeling - advantages, disadvantages and usefulness - Abstract (PDF); Slides (PDF) | Rada Savic (bio) | ||
| Assessing Nonlinear Mixed Effects Model Parameter Estimates via Profiling of the True Likelihood - Abstract (PDF); Slides (PDF) | Paolo Vicini (bio) | ||
| Modelling Overdispersion and Markovian Features in Count Data - Abstract (PDF); Slides (PDF) | Inaki Troconiz (bio) | ||
| Standardization of Data Collection for Literature Based Meta-Analyses: The Literature Information and Knowledge Explorer (LIKE) Initiative. - Abstract (PDF); Slides (PDF) | Brian Corrigan (bio) | ||
| 10:20-11:20 am | Break/Posters/Software Demos | ||
| 11:20 am -12:45 pm | Focus Session 4: Communication Session Chairs: Stacey Tannenbaum and Peter Bonate |
||
| Opening remarks | Stacey Tannenbaum | ||
| And Now Presenting... YOU. Make Your Message Matter - Abstract (PDF); Slides (PDF, PDF) | Peter Bonate (bio) and Don Berk (bio) | ||
| 12:45-1:45 pm | Lunch/Posters/Software Demos | ||
| 1:45-3:30 pm | Focus Session 5a: Exposure Response Session Chairs: Nick Holford and Ene Ette |
||
| Exposure – Response and Drug Development in the 21st Century - Abstract (PDF); Slides (PDF) | Ene Ette (bio) | ||
| Evolution of the Exposure Response Guidance: Regulatory and Industry Perspective - Abstract (PDF) | Raymond Miller (bio) | ||
| Why we need to Study Schedule Dependence - Abstract (PDF); Slides (PDF) | Ellen Feigal (bio) | ||
| Population pharmacokinetics of clobazam and its active metabolite in pediatric patients with epilepsy: Effect of weight, genotype and co-therapy. - Abstract (PDF); Slides (PDF) | Manisha Lamba (bio) | ||
| Parallel PK/PD modeling of an endogenous agonist (A) and exogenous antagonist (B) based on research PKPD data to predict an effective first-in-man dose of B: a combination of physiologically based PK and population PKPD - Abstract (PDF); Slides (PDF) | Nele Plock (bio) | ||
| Dose-Response Modeling for Combination Drug Products - Abstract (PDF) | Susan Willavize (bio) | ||
| 3:30-4:30 pm | Break/Posters/Software Demos | ||
| 4:30-6:00 pm | Focus Session 5b: Altering Disease Progression Session Chairs: Nick Holford and Ene Ette |
||
| How Drugs May Slow Disease Progression - Abstract (PDF); Slides (PDF) | Nick Holford (bio) | ||
| Endpoints and Analysis to Discern Symptomatic and Disease Modifying Drug Effects on Parkinson’s Disease for Delayed Start Design - Abstract (PDF); Slides (PDF) | Pravin Jadhav (bio) | ||
| Washout of treatment effects is essential for distinguishing short (symptomatic) and long-term (disease modifying) treatment effects from natural disease progression - Abstract (PDF); Slides (PDF) | Bart Ploeger (bio) | ||
| Model-Based Literature Meta-Analysis: Virtues and Limitations - Abstract (PDF); Slides (PDF) | Farkad Ezzet (bio) | ||
| Characterizing Longitudinal Pulmonary Function (FEV1) Decline in Continuous Smokers Using a Turnover Model - Abstract (PDF); Slides (PDF) | Song Mu (bio) | ||
| 6:30 pm -??? | ACoP Social Event: Sonoran Desert Fiesta | ||
| WEDNESDAY MARCH 12 | |||
| 8:00 - 9:00 am | Breakfast | ||
| 9:00-10:55 am | Focus Session 6: Benefit-Risk Assessment Session Chairs: Raymond Miller and Kevin Dykstra |
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| Opening remarks | Kevin Dykstra (bio) | ||
| Enhancing Benefit-Risk within Drug Development - Abstract (PDF); Slides (PDF) | Peter Milligan (bio) | ||
| Cutting the Gordian Knot: Learn High Value Information Quickly for Better Decision-making - Abstract (PDF); Slides (PDF) | Bob Korsan (bio) | ||
| Benefit/risk assessment - Going beyond exposure/clinical outcome - Abstract (PDF); Slides (PDF) | Uche Iloeje (bio) | ||
| Modeling and Simulation to Determine Optimal Schedule for An Orally Administered Cytotoxic Drug - Slides (PDF) | Amit Roy (bio) | ||
| Integrating PK-PD and statistics to support decision making in clinical drug development of corifollitropin alfa: a case study in controlled ovarian stimulation - Abstract (PDF) | Rik de Greef (bio) | ||
| Panel discussion | |||
| 10:55-11:10 am | Break | ||
| 11:10 am - 12:15 pm | Focus Session 7: Impact/Outlook Session Chairs: Raymond Miller and Marc Pfister |
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| M&S Can Change the World! | Marc Pfister | ||
| A Model-Based Framework for Quantitative Decision-Making in Drug Development - Abstract (PDF); Slides (PDF) | Ken Kowalski (bio) | ||
| Impact of M&S on advances in translational research - Abstract (PDF); Slides (PDF) | Jeff Barrett (bio) | ||
| Pharmacometrics 2020 - Abstract (PDF); Slides (PDF) | Joga Gobburu (bio) | ||
| 12:15-12:30 pm | Closing Remarks | Stacey Tannenbaum | |
| END OF CONFERENCE | |||
| 1:00 - 3:00 pm | Boxed lunch and nature walk (optional) | ||
| 1:00 - 3:00 pm | ACoP Faculty meets to discuss next ACoP (lunch) | ||
| 12:30 - 6:30 pm Wed | Post-meeting workshop: Binary and Categorical Data Modeling, Analysis and Simulation using NONMEM® | Adrian Dunne and ICON staff | |
| 9:00 am - 5:00 pm Thurs | |||